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Last Updated September 2016. Note this is very much a work in progress. This index now lists all of the Victor Annuals and the 1968, 1969, 1970. Operation Downfall was the codename for the Allied plan for the invasion of Japan near the end of World War II. The proposed operation was abandoned when Japan. The Official Story of Oradour-sur-Glane. The official story of the massacre at Oradour-sur-Glane is told in a 190-page book entitled 'Oradour-sur-Glane, a. With so many tests for students and many people still skeptical of the Partnership for Assessment of Readiness for College and Careers, or PARCC, Herald-Mail Media. Welcome to the Military Gallery, publishers of Robert Taylor, Nicolas Trudgian, Simon Atack, and other leading aviation, marine, and military artists. Audie Murphy’s single handed battle, kills 5. Winter in northwestern Europe, 1. Ardennes front. Audie L. Murphy had come a long way since he had landed in Sicily in 1. Corporal and the runner for B Company, 1. Infantry Regiment. A string of promotions and medals had been accompanied by a number of wounds and incapacitation with Malaria. In October 1. 94. Silver Stars and a battlefield commission – but had also been shot in the leg and during subsequent hospital treatment had had muscle removed after gangrene set in. Many men would have taken a long time to recover from such a wound but in January 1. Murphy rejoined his regiment and soon was back in the thick of the action. On January 2. 3, the 3. Regiment, 3rd Infantry Division had reached the outskirts of the village of Holtzwihr, the wooded area known as the Bois de Riedwihr. They suddenly encountered 1. On the 2. 5th Company B of, 1st Battalion, 1. Regiment was ordered to attack the same ground again. Losing six out of seven officers and 1. The eighteen surviving men led by Murphy found it impossible to dig foxholes because of the frozen ground – but they were re- inforced by some Tank Destroyers before dawn and later by a Forward Artillery Observer. Audie Murphy describes the position on the 2. German counter- attack which must inevitably come. Their orders were to hold the position and wait for re- inforcements: Checking the other men, I find that our right flank is exposed. Some unit failed to get up on schedule. A forward artillery observer with a radio joins us. The icy tree branches rattle in the wind. Citation: The President of the United States takes pleasure in presenting the Silver Star Medal to Andrew J.By the summer of 1944, the ordinary Again I contact headquarters. Hold your position.”At two o’clock in the afternoon, I see the Germans lining up for an attack. Six tanks rumble to the outskirts of Holtzwihr, split into groups of threes, and fan out toward either side of the clearing. Obviously they intend an encircling movement, using the fingers of trees for cover. I yell to my men to get ready. Then wave after wave of white dots, barely discernible against the background of snow, start across the field. They are enemy infantrymen, wearing snowcapes and advancing in a staggered skirmish formation. One of our tank destroyers starts its engine and maneuvers for a firing position. It slides into a ditch at an angle that leaves the turret guns completely useless. The driver steps on the gas; the tank wallows further into the ditch; the engine dies. The crew bails out and takes off for the rear.“I’m trying to contact headquarters,” shouts the artillery observer. I had forgotten about him. We cannot afford to have the radio captured. You can’t do any good. Just take care of that radio.”I grab a map, estimate the enemy’s position, and seize the field telephone. Get me the artillery.” “Coming up.”“I want a round of smoke at co- ordinates 3. How many krauts?” “Six tanks that I can see, and maybe a couple hundred foot soldiers supporting.” “Good god! How close?” “Close enough. Give me that artillery.”I hang up the receiver and grab my carbine just as the enemy’s preliminary barrage hits. A single tree burst knocks out our machine- gun squad. The second tank destroyer is hit flush, and three of its crew are killed. The remainder, coughing and half- blinded, climb from the smoking turret and sprint down the road to the rear. At that moment I know that we are lost. The smoke shell whizzes over, landing beyond the oncoming Germans. And fire for effect. Our counterbarrage is on the nose. A line of enemy infantrymen disappear in a cloud of smoke and snow. But others keep coming. The telephone rings. The tanks are now close enough to rake our position with machine- gun fire. Of the hundred and twenty- eight men that began the drive, not over forty remain. And I am the last of seven ofiicers. Trying to stop the armor with our small arms is useless. I yell to the men to start pulling out.“What about you?” shouts Kohl. Get the men back, and keep them grouped. Candler will help you.” “Candler’s dead.”The telephone rings. The company’s pulling back.” I raise my eyes and see that the men are hesitating. Clapping down the receiver, I yell, “Get the hell out of here. That’s an order!”Kohl says something, but his words are lost in a shell burst. He shrugs his shoulders, beckons with his thumb, and the men stumble through the woods, casting worried glances backward. I seize my carbine and start sniping. The advance wave of infantrymen is within two hundred yards of my position. The telephone rings. Keep it coming.” Dropping the receiver, I grab the carbine and fire until I give out of ammunition. As I turn to run, I notice the burning tank destroyer. On its turret is a perfectly good machine gun and several cases of ammunition. The German tanks have suddenly veered to the left. See Audie Murphy: To Hell and Back. A German picture of their troops successfully attacking during January 1. The official citation for the Medal of Honor: Second Lieutenant Audie L. Murphy, 0. 16. 92. Infantry, Army of the United States, on 2. January 1. 94. 5, near Holtzwihr, France, commanded Company B, which was attacked by six tanks and waves of infantry. Lieutenant Murphy ordered his men to withdraw to a prepared position in a woods while he remained forward at his command post and continued to give fire directions to the artillery by telephone. Behind him to his right one of our tank destroyers received a direct hit and began to burn. Its crew withdrew to the woods. Lieutenant Murphy continued to direct artillery fire which killed large numbers of the advancing enemy infantry. With the enemy tanks abreast of his position, Lieutenant Murphy climbed on the burning tank destroyer which was in danger of blowing up any instant and employed its . He was alone and exposed to the German fire from three sides, but his deadly fire killed dozens of Germans and caused their infantry attack to waver. The enemy tanks, losing infantry support, began to fall back. For an hour the Germans tried every available weapon to eliminate Lieutenant Murphy, but he continued to hold his position and wiped out a squad which was trying to creep up unnoticed on his right flank. Germans reached as close as 1. He received a leg wound but ignored it and continued the single- handed fight until his ammunition was exhausted. He then made his way to his company, refused medical attention, and organized the company in a counterattack which forced the Germans to withdraw. His directing of artillery fire wiped out many of the enemy; he personally killed or wounded about 5. Lieutenant Murphy’s indomitable courage and his refusal to give an inch of ground saved his company from possible encirclement and destruction and enabled it to hold the woods which had been the enemy’s objective. A post war photograph of Murphy in dress uniform complete with all his medals. Now famous as the the most decorated soldier in the U. S Army he was to go on to have a successful career in Hollywood. Mard (1985) Cast: Amitabh Bachchan, Amrita Singh, Dara Singh Randhawa, Prem Chopra, Joginder, Bob Christo, Nirupa Roy, Seema Deo, Dan Dhanoa, Goga Kapoor, Kirti Kumar. Listen to Hindi songs from Mard. ADHM once again proves if you don’t have good and coherent script no matter how big production house or director is making the movie, the movie cannot win audience. Download Mard (1. Mp. 3 Songs. Genre: Indian Movies Hindi Mp. Songs. Album Name: Mard (1. Description: Mard (1. Indian Movies Hindi Mp. Songs. Download and Listen to Mard (1. Mp. 3 Songs. Mard (1. 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It is commonly believed that the in vivo damage of biomolecules is initiated by reactive oxygen species (ROS) in a process known as oxidative stress. However, oxidation reaction in biological systems may also occur via a nonradical pathway, for example, by hydrogen peroxide. In such cases, the products of its action are molecules that are enriched in one or more oxygen atoms that are generally considered to be markers of oxidative stress. Yet mere presence of extra oxygen does not tell us whether a given product is generated by a single- (free radical) or two- electron oxidation reaction. It should be emphasized that, according to the concept of oxidative stress, peroxidation and degradation of vulnerable biological molecules is caused by oxygen- centered radicals generated, in turn, by excessive blood oxygenation. Created by Hal McElroy, Tony Morphett, John Hugginson. With Brett Partridge, Peter Bensley, Toni Scanlan, Jay Laga'aia. Beneath its surface exists a playground for. However, this conclusion is based on studies of ischemia/reperfusion cases in which periods of prolonged hypoxia are followed by a sudden supply of oxygen. For example, in patients with extracorporeal circulation the appearance of lipid and/or nucleic acids oxidation products is accepted as signs of oxidative stress. However, a very important fact is being neglected, namely, that the most biologically active hydroxyl radicals are being predominantly formed during the period of ischemia in which oxygen is in short supply. The uncritical acceptance of the fact that the presence of additional oxygen atom(s) in biomolecules and in their degradation products is a sign of oxidation led to a misleading definition of what is an antioxidant. According to principles of electrochemistry antioxidant must be endowed with a reductive property, but except ascorbic acid (vitamin C) and glutathione, there are very few natural substances that have reducing properties . Therefore, it is not surprising that ascorbic acid has not only failed to prevent consequences of oxidative stress . These facts present a paradox exemplified by a failure to demonstrate a significant effect of antioxidant therapies in diseases believed to be associated with oxidative stress, for example, atherosclerosis . Several attempts were made to explain this problem in a series of publications . Another line of evidence showing the lack of benefits from the use of antioxidants is their ineffectiveness in the prevention or treatment of hypertension . By contrast, a diet rich in fruits and vegetables and whole grains protects cardiovascular system and lowers blood pressure by reducing free radical stress . These important, albeit controversial, issues are being reviewed in this paper. Generation and Properties of Hydroxyl Radicals. In living organisms there are two major reactive oxygen species, superoxide radical and hydroxyl radical that are being continuously formed in a process of reduction of oxygen to water. In the Haber- Weiss reaction hydroxyl radicals are generated in the presence of hydrogen peroxide and iron ions. The first step involves reduction of ferric into ferrous ion. The second step is the Fenton reaction: The requirement of hydrogen peroxide in the Fenton reaction led to the misleading concept of oxidative stress that ignores the fact that hydroxyl radical (), known to be the most biologically active free radical, is formed in vivo under hypoxic conditions . Moreover, this free radical can be generated in vitro under the reducing condition in the presence of ascorbic acid and iron ions. Even more intriguing is a discovery, presented in this paper, of the generation of hydroxyl radicals catalyzed by ferric ions without any additional redox agent, which can be considered as a special case of the Fenton reaction. It was suggested some years ago that iron therapy might promote the formation of hydroxyl radicals thus contributing to atherosclerosis . In connection with this, it is of importance to note that excessive accumulation of stored iron is observed in atherosclerotic lesion . In his paper with 1. Brewer reviewed the roles of both iron and copper in aging- related diseases . More recently, another comprehensive review of the role of iron in degenerative diseases was published . The close relationship between iron overload and pathogenesis of chronic disease can be explained in terms of the iron- induced hydroxyl radical generation and subsequent deposition of a fibrin- like material in various organs. Hydroxyl Radical- Induced Polymerization of Human Fibrinogen. Fibrinogen is the most hydrophobic blood protein and thus it is very unstable in aqueous solutions being readily adsorbed on various surfaces . In fact, the conversion of fibrinogen to fibrin by the action of thrombin renders fibrin monomers even more hydrophobic thus facilitating their spontaneous polymerization . Moreover, exposure of purified fibrinogen to the ascorbic acid/cupric ion system results in the formation of an insoluble fibrin- like precipitate (neofiber) . It was then serendipitously discovered that such a dramatic modification of fibrinogen is caused by hydroxyl radicals generated in the presence of ferric ions without any redox agent. As can be seen in Figure 1, the amount of precipitated fibrinogen is proportional to the number of hydroxyl radicals generated in the system. Figure 1: Effect of iron (ferric chloride) on fibrinogen aggregation, as measured by optical density, and on hydroxyl radical generation expressed as fluorescence intensity according to Manevich et al. Fifty- microliter aliquots of ferric chloride solution at various molar concentrations were added to black plastic microplate wells containing each 1. The results presented in this figure show that the aggregation of fibrinogen is closely related to the extent of hydroxyl radicals generated in the system. Formation of insoluble aggregates under the influence of hydroxyl radicals is due to a limited reduction of intramolecular disulfide bridges followed by exposure of buried hydrophobic epitopes leading to the formation of extremely strong intermolecular bonds. Interestingly enough, acetylation of fibrinogen prior to the reaction with hydroxyl radicals rendered it susceptible to fibrinolysis . It is very likely that this effect of salicylates is due to the introduction of a negative charge to the protein, thus diminishing hydrophobic interactions. An example of the effect of negative charge of sulfate groups is sulfitolysis of proteins that completely unfolds their polypeptide chains and yet maintains their complete solubility. It should be noted that fibrin- like deposits, which are remarkably resistant to proteolytic degradation, have been observed in numerous degenerative diseases such as atherosclerosis . The same pathological conditions are characterized by excessive accumulation of poorly liganded iron, thus implicating a potential role of hydroxyl radicals in pathogenesis of these diseases . Antioxidants and Free Radical Scavengers. There is a belief that polyunsaturated fatty acids (PUFAs) contribute to oxidative stress by providing a source of lipid peroxides. Yet by contrast to such expectations and according to epidemiological studies, PUFAs exert beneficial effects in those diseases that are known to be associated with free radical generation . Another example of protective effect of unsaturated fatty acids is an intriguing phenomenon of the lack of signs of peroxidation in ringed arctic seals. These marine mammals hunt for fish by diving for periods of time up to 3. Thus, it must be concluded that PUFAs present in their body fat protect these animals from the damaging consequences of prolonged hypoxia. This phenomenon can be explained in terms of a hydroxyl radical scavenging capacity of double bonds of polyunsaturated fatty acids. Both omega- 3 fatty acids and polyphenolic natural substances were shown to have protective effect in Alzheimer's disease . This apparent paradox can be explained by a strong affinity of hydroxyl radicals to double bonds that become reduced to single bonds . In the case of unsaturated fatty acid (PUFA) the product formed is a hydroxy- fatty acid, which, in the presence of molecular oxygen, is further oxidized to aldehydes and ketones. This very important fact is an ultimate source of confusion, since these specific peroxidation products are considered to be markers of oxidative stress. In addition to the aforementioned substances, certain biologically active agents containing phenolic rings have the capacity to scavenge hydroxyl radicals by virtue of aromatic hydroxylation at the orthoposition. One of such recently discovered scavengers is resveratrol shown to have a protective effect on ischemia- induced cerebral neuron damage . Salicylates, that belong to the class of drugs with available orthoposition at their phenolic ring, have also been demonstrated to protect against free radical injury in vitro . The beneficial effect of salicylic acid in diabetes mellitus was first observed almost 1. The Latest US and World News. 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Muitas. pessoas hoje sabem mais sobre os produtos de baixa qualidade da China do que. Sequer conhecemos a hist. Death by Government, por R. J. Rummel (Transaction, 1. Hungry Ghosts: Mao's Secret Famine, por Jaspar Becker (Owl Books, 1. |
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